Name: THE ROLE OF INFLAMMATION IN CARDIOVASCULAR DISEASE - Periodic Series
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THE ROLE OF INFLAMMATION IN CARDIOVASCULAR DISEASE

Authors: Dr. Neha Gupta, Aditya Verma

Pages: 37-51

Abstract

The immune system has a major contribution to the initiation and progression of atherosclerosis, a chronic inflammatory condition. Significantly, cardiovascular diseases (CVDs), to which atherosclerosis is a major contributor, are the number one cause of death worldwide, responsible for about 31% of total deaths, and a major cause of illness globally, as per the World Health Organization (WHO). These are the world's most important health problems. Among the chronic heart conditions include arrhythmia, congestive heart failure, myocardial infraction, heart stroke, coronary artery disease, cardiac ischemia, and atrial fibrillation; early detection of these conditions may lower the death rate. Traditional diagnosis of these heart diseases is done by the physical examination of the reports related to concerned symptoms of patient with the reports of his medical history. Analysis done through these methods may not be accurate in detection of heart diseases and it also expensive and time consuming because these diseases require continuous monitoring. Low-density lipoprotein cholesterol oxidizes inside the artery wall. Furthermore, residual lipoproteins and lipoproteins high in triglycerides have pro-inflammatory properties, which is mediated by an increase in sympathetic output that releases inflammatory cytokines. Through an increase of leukocyte clones in peripheral circulation, inflammation also serves as a link between aging and cardiovascular disease Ho (2018).

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