NOVEL THERAPEUTIC STRATEGIES FOR ALZHEIMER’S DISEASE
Abstract
Alzheimer's disease (AD) is an advanced stage of dementia that gradually worsens memory loss, impairs thinking abilities, and makes it harder to complete basic tasks. The disease is called Dr. Alois Alzheimer, in the year 1906. The loss of connection between neurons in the brain, which transmits information to the body's organs, is another effect of AD. The hippocampus, which stores memories, is first affected by AD. Later, it spreads to other parts of the brain and causes it to shrink. The brain would have considerably decreased by the time AD reached its most severe stage. It has been noted that not every memory loss issue results in AD. The majority of AD symptoms vary from patient to patient and are not universal. Not all patients with moderate cognitive impairment (MCI) develop Alzheimer's disease (AD), despite MCI being a warning indication of AD. Because AD patients may not be able to perform their own responsibilities, the majority of them get anxious, and some of them become more aggressive. These drugs simply stop the decline of cognitive capacities and momentarily relieve symptoms. In this article, we first address the drawbacks of anti-Aβ treatments, such as their low effectiveness and possible side effects, which emphasize the need to look into different targets and processes. We next go over intriguing non-Aβ-based approaches such gene and stem cell therapy, neuroinflammation management, and tau-targeted therapeutics. These approaches offer new therapeutic possibilities for AD by tackling downstream consequences and other disease markers besides Aβ buildup
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